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A Lethal Dose of Caffeine

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By Eugene Y. Chan, M.D.

Recent news about tragic death of Anais Fournier hit the web.  She was 14 and she died after consuming two 24-ounce Monster Energy drinks over a 24-hour period.  She had an underlying heart arrhythmia that may have predisposed her to the adverse effects of caffeine.

Caffeine is a small molecule alkaloid that is found in many different types of plants.  It has a receptor-based mechanism of action that antagonizes the action of adenosine.  In clinical medicine, adenosine is sometimes utilized to treat certain irregular heartbeats, including some supraventricular tachycardias.  Decreasing the action of adenosine can therefore lead to a faster heart rate and can also predispose the heart to irregular heartbeats.  In the case of the very unfortunate 14-year old, she consumed caffeine which decreased action of the adenosine, thus increasing her likelihood of a fatal arrhythmia.

How much is too much?  One may say, “Let us calculate the lethal dose.”  The LD50, or lethal dose for killing 50% of tested animals, for rats is 192 mg/kg.  Extrapolating this to a 14-year old weighing 50 kg, this LD50 is 9.6 grams of caffeine.  Of course, these studies were not conducted in humans so this is only a ballpark estimate.  In a typical energy drink, there is approximately 200 – 300 mg of caffeine, although in some energy drinks, the actual amount is unclear, based on how the products are labeled.  We can assume that Anais probably consumed < 1 gram of caffeine from her two energy drinks, yet this was a fatal dose for her.  What the LD50 calculation is missing is both an understanding of both statistics as well as pharmacogenomics.  Statistics tells us that some individuals may very well have adverse events at a much lower dose of caffeine.  Part of this is based on a genetic makeup and how we react to certain molecules.  This is called pharmacogenomics.  In the case of Anais, she likely had a genetic cause of her underlying cardiac arrhythmia.  She may very well have been a slow metabolizer of caffeine, also based on her genetic makeup, leading this molecule to linger in her system much longer than that of her counterparts.  Without a whole genome study, of course, we would never know.

Overall, the lesson here is that receptor-based molecules, such as caffeine, can be extremely dangerous, depending on the specifics of your medical and genetic background.  For most people it may be fine, for others, it can unfortunately take push you over the threshold of safety.

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Why you need mental clarity

By Eugene Y. Chan, MD

Somewhere around 3 AM in the morning at the Massachusetts General Hospital one day, I remember a particular instance of having to draw blood from a very ill patient.  By that time, I had already worked for 20 hours straight, with my beeper ringing every few minutes.  What is so urgent that requires a blood draw at this hour?  I looked at the patient’s medical record and saw a history of HIV and HCV.  This patient was in renal and liver failure.  I looked for a suitable vein in the antecubital fossa but could not find any.  I look elsewhere on the arm, but still no.  My eyes were feeling heavy from my day and also staring closely in the dark to look for a thin blue vein that I could target.  Finally, I found a potential vein, on the dorsal surface of the foot.  It was so thin and collapsed, but it was my only hope.  I knew that if I were not careful, I could indeed inadvertently stick myself, which could put me at risk for both HIV and HCV.  I also knew that I did not draw the patient’s blood, she would have a high likelihood of not making it through the night.  It is in times like this, where if your mind wanders, even for a brief moment, the outcome would be highly undesirable.  This is when you need mental clarity, this is when you need that moment of unwavering focus.  Have you been in a circumstance like this?  Maybe not treating a patient, but interviewing for a most coveted job, giving the most important sales presentation, or pushing yourself to win that race?  Fortunately, the outcome that morning was positive, the important medical tests were highly informative for the course of her care and the patient made it through the night.  There are situations like that that arise often, and often unexpected, and you have to be prepared to make those yours.  Stay focused and be at your best, always.

Clarex’s Busy Weekend!

Clarex was all over the place this past weekend. We were at the Whole Foods in Cambridge and Newton, cheering on bicycle riders as they began a trip from Boston to Raleigh, handing out samples with HubHelmet and even at Fenway Park! Clarex was stocked on the shelves, and great times were had by all.

The day began as early as 8 for our Street Team, who were up bright and early to attend the The Pablove Foundation’s long-distance bike ride.It funds pediatric cancer research and programs to improve the quality of life for children living with cancer.The 1000-mile bike ride from Boston to Raleigh began with a nice breakfast for riders, family, and supporters to chat and enjoy at the Whole Foods on Prospect St. in Cambridge. Not to mention we had our team there handing out samples and taking photos of the event, which you can view here. The kickoff also had another perk for Clarex-our product was officially on the shelves! What an accomplishment! So be sure to visit the Whole Foods on Prospect St. to buy Clarex directly along with your other groceries.

Meanwhile, Captain Clarex was at the Whole Foods in Newton, setting up his demo. Clarex is also now sold at the Whole Foods in Newton, and many people got to learn about eliminating mental limits with Clarex. There were trial sizes to test out, and the product being sold right there in the store for those who wanted to continue to increase their focus. After all, Clarex is all natural and caffeine-free!

We also had some samples to give away with HubHelmet, a new service that allows Hubway users access to helmets for safe riding. Be sure to look out for HubHelmet available with all Hubway stations soon! Clarex was a big hit, and it’s great for bike riding so you can focus more on your ride and enjoy it.

Clarex was also at Fenway Park this Saturday as well! After attending teh Pablove Foundation’s kickoff event, Team Clarex attended College Day @ Fenway. where lots of college students received samples. Everyone there had a fantastic time, especially our street team members who got to pose with the World Series trophies! Check out the photos here.

And to think this is just the beginning! Keep on the lookout for Clarex on our Facebook page to learn where we will be next. Comment with any suggestions or feedback-we love to hear from our fans!

-Team CLAREX

Breaking Down the Intelligent Workout with Eric Ballenger

Eric Ballenger

Welcome to the Clarity Corner! I’m Eric Ballener, and a daily Clarex user. As a fitness enthusiast, my background includes ISSA, ACE, NFPT certified, certified personal trainer, former NPC competitor, and a Pre-Contest Prep Coach. I’ll be posting regularly with all things fitness, so check back often! Feel free to comment with any questions to answer in future posts.

What we do before we work out can be just as important as any exercise we do during our workout. Pre-workout preparation has been studied, dissected, and argued about since before Arnold lifted his first barbell. .Let me back up here for a second, we’re not just talking about the gym rats. (You know who you are, because I’m one too!) I’m talking about the triathlete, the cyclist, the runner, the CrossFit enthusiasts, the powerlifter, and even the bodybuilder. We are all familiar with the term “muscle memory.” Muscle memory has been used along simultaneously with motor learning, which is a form of procedural memory that involves consolidating a specific motor task into memory through repetition.

In other words, every Monday, we wake up thinking today is chest day and our mind prepares our body for the trauma that it will endure during a typical workout. We have all been there. We take the thermogenic gotten the jitters the heart palpations the sweats but what did we really accomplish? We have once again attacked our receptor sites and overstimulated our adrenal glands.  Through the use of Clarex, I have personally found a new form of laser focus while in the gym. Though I still enjoy my heavily caffeinated and synephrine based pre-workout RTD, I have now added Clarex as a complement to my regimen.

This is where “The Intelligent Workout” begins. I take my Clarex with my thermo 30-45 minutes pre-workout. The most profound and lasting impact of Clarex on my workout is found in the level of clarity that did not exist before, I no longer find myself asking what exercise is next. Rather, I find myself with that feeling of complete focus and concentration.

As a result, my workouts have become more intense, and shorter in duration. Let me reiterate. CLAREX IS NOT A THERMOGENIC! Clarex is a stimulant-free complement to any pre-workout regimen. Clarex, when taken as directed, can help you get the most out of every workout no matter what hurdles life has thrown at you before you step through the gym doors. So try Clarex today, “Eliminate YOUR Mental Limits” and unlock your body’s full potential with no side effects and no crash.

-Team CLAREX

How to take Clarex

Clarex was made to eliminate mental limits and give you focus when taken properly. That being said, it’s time we told you the proper way to take Clarex to get the maximum effects it can offer. We base the amount you need to take from your Body Mass Index (BMI). If you’ are curious what your BMI is, click here to find out what yours is.

But for the best results, adults under 150lbs should take 1 tablet. If you weigh over 150lbs, 2 tablets will give you your best results. Take Clarex with at least 8oz of fluids, and adjust the dosage as needed according to exertion or activity.

Clarex is a mental clarity recovery formula meant to improve focus, concentration, and overall feeling of well-being. To achieve this level of clarity, take one tablet daily. Because Clarex is a stimulant free product, there is no risk of overdose or drug interaction. When taken as directed, users should feel the effects of Clarex within one week. Our all natural product typically will give users 4-5 hours of clear mental focus, improving performance.

Clarex can also be used as hangover relief, or as we like to call it at Clarex “Post-Celebratory Recovery.” With several key vitamins that lead of focus and mental clarity, Clarex can make that morning after a lot more enjoyable.

Now that you know a bit more about Clarex and how to use it, it’s time to take that next step and order Clarex by clicking here.

Eliminate mental limits today!

-Team CLAREX

Jon Chafe

Jon Chafe

Meet Jon Chafe, our CLAREX representative in Canada. We are very excited to have Jon as part of our team here at CLAREX. An avid user, Jon has improved his focus and gotten the most out of his workouts.

-Team CLAREX

Clarex on the T

Clarex on the T

Bostonians, be sure to be on the lookout for our marketing campaign on the MBTA trains. Posters have been placed on Red and Green lines, and will be up until 10/24. If you want to see more pictures, click the image to view the album on our Facebook page!

Comment here if you’ve seen one of the posters!
-Team CLAREX

Meet Team Clarex!

Here at Clarex, we are all about Eliminating Mental Limits. Our mental clarity recovery formula can offer a lot-whether you’re looking for a study aid, intelligent workout, or hangover relief. Now that you have an idea what Clarex is all about, it’s time to meet the team that is Clarex.

 

Dr. Eugene Chan

 

Dr. Eugene Chan formulated Clarex as a study aid. Caffeine free, Clarex all-naturally provided focus without and crash or side effects. A Harvard graduate, Dr. Chan discovered Clarex increased brain function while increasing concentration and motor skills. His work has been featured in several magazines, including Esquire, Forbes, Fortune, Newsweek, and the New York Times. He is the Founder, President, and Chief Scientific Officer of the DNA Medicine Institute, an organization focused on advancing patient care, alleviating human suffering, and treating disease through innovation.

 

 

 

Eric Ballenger

Eric Ballenger, Florida native and Clarex Marketing Director takes Clarex daily. As a former competitive bodybuilder, Eric knows what it takes to go the distance, and Clarex is one of those necessities. He saw the benefit of Clarex, realizing it helped increase his concentration, leading to more productive workouts. The “intelligent workout” with Clarex helps you make the most of your workout, giving you 100% focus on the task at hand.

 

 

 

 

So there’s a quick introduction to some of the Clarex team! Feel free to comment with any questions for either Dr. Chan or Eric to reply to in upcoming posts.

Experience no limits safely with Clarex, and check back often!

-Team CLAREX

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