By Eugene Y. Chan, MD
The holidays are approaching us fast and typically there are two big fears that confront us: (1) how do I not gain weight? and (2) how do I survive my holiday party? Thanksgiving and the holidays are synonymous with gluttony, binge eating, and over indulgence. Furthermore, there are numerous holiday parties that you need to attend, whether out of obligation or for fun. Given the joyous time of year, there is plenty of opportunity to get carried away. Fortunately, there is time to prepare.
First, regarding weight gain, there are several key realizations. The first is that the stomach has unique properties. It is an expandable container, made of smooth muscle. If it is in a compact state for weeks prior to your binge eating episode, you will feel full faster and will not consume as much. On the flip side, if you occasionally have large meals, you stomach will have lost its elasticity, very much like a balloon that has been inflated and deflated multiple times, and you will be able to consume a lot more. Second, your stomach and digestive tract secrete enzymes that require a certain time of upregulation, through gene expression and protein translation. Without certain key enzymes, the nutrients of certain foods do not make it into the body. So you could utilize this to your advantage. If you avoid fatty foods routinely, it is unlikely that a single meal of fatty foods will lead to significant weight gain. The lesson here in understanding the anatomy of your stomach as well as the molecular response of it to food is simple: if you eat healthy and in small portions on a routine basis, the impact of a single large meal is unlikely to have significant impact on your daily trip to the scale. Of course, it all goes without saying that you should continue to remain active and exercise often.
Ok, what should you do about those holiday parties? Holiday parties tend to be a great time to network, build camaraderie with your colleagues, all through a relaxed atmosphere. Part of this is a liberal amount of beer, wine, and cocktails that loosen up even your stiffest co-worker. The key here is moderation for you. Since you don’t want to be the individual that gets talked about the day after, setting a drink limit and goal for yourself prior to the party is most important. Discussing your goals with a colleague of similar professional mindset would help you solidify your resolve. In the event you did have one too many, how do you make it to work? The answer is simple: drink plenty of water and take a product designed for post-celebration recovery. The key is to get your Kreb’s cycle back up and running since an excess of ethanol builds up NADH, which signals the Kreb’s cycle to slow down. As you know the Kreb’s cycle is central to generating ATP, your body’s main form of energy. By supplementing key cofactors for enzymes in your Kreb’s cycle, you can get it back up and running in no time, and feel great in the process.
With that, good cheers for the holidays and be well.
By Eugene Y. Chan, M.D.
Recent news about tragic death of Anais Fournier hit the web. She was 14 and she died after consuming two 24-ounce Monster Energy drinks over a 24-hour period. She had an underlying heart arrhythmia that may have predisposed her to the adverse effects of caffeine.
Caffeine is a small molecule alkaloid that is found in many different types of plants. It has a receptor-based mechanism of action that antagonizes the action of adenosine. In clinical medicine, adenosine is sometimes utilized to treat certain irregular heartbeats, including some supraventricular tachycardias. Decreasing the action of adenosine can therefore lead to a faster heart rate and can also predispose the heart to irregular heartbeats. In the case of the very unfortunate 14-year old, she consumed caffeine which decreased action of the adenosine, thus increasing her likelihood of a fatal arrhythmia.
How much is too much? One may say, “Let us calculate the lethal dose.” The LD50, or lethal dose for killing 50% of tested animals, for rats is 192 mg/kg. Extrapolating this to a 14-year old weighing 50 kg, this LD50 is 9.6 grams of caffeine. Of course, these studies were not conducted in humans so this is only a ballpark estimate. In a typical energy drink, there is approximately 200 – 300 mg of caffeine, although in some energy drinks, the actual amount is unclear, based on how the products are labeled. We can assume that Anais probably consumed < 1 gram of caffeine from her two energy drinks, yet this was a fatal dose for her. What the LD50 calculation is missing is both an understanding of both statistics as well as pharmacogenomics. Statistics tells us that some individuals may very well have adverse events at a much lower dose of caffeine. Part of this is based on a genetic makeup and how we react to certain molecules. This is called pharmacogenomics. In the case of Anais, she likely had a genetic cause of her underlying cardiac arrhythmia. She may very well have been a slow metabolizer of caffeine, also based on her genetic makeup, leading this molecule to linger in her system much longer than that of her counterparts. Without a whole genome study, of course, we would never know.
Overall, the lesson here is that receptor-based molecules, such as caffeine, can be extremely dangerous, depending on the specifics of your medical and genetic background. For most people it may be fine, for others, it can unfortunately take push you over the threshold of safety.
By Eugene Y. Chan, MD
Somewhere around 3 AM in the morning at the Massachusetts General Hospital one day, I remember a particular instance of having to draw blood from a very ill patient. By that time, I had already worked for 20 hours straight, with my beeper ringing every few minutes. What is so urgent that requires a blood draw at this hour? I looked at the patient’s medical record and saw a history of HIV and HCV. This patient was in renal and liver failure. I looked for a suitable vein in the antecubital fossa but could not find any. I look elsewhere on the arm, but still no. My eyes were feeling heavy from my day and also staring closely in the dark to look for a thin blue vein that I could target. Finally, I found a potential vein, on the dorsal surface of the foot. It was so thin and collapsed, but it was my only hope. I knew that if I were not careful, I could indeed inadvertently stick myself, which could put me at risk for both HIV and HCV. I also knew that I did not draw the patient’s blood, she would have a high likelihood of not making it through the night. It is in times like this, where if your mind wanders, even for a brief moment, the outcome would be highly undesirable. This is when you need mental clarity, this is when you need that moment of unwavering focus. Have you been in a circumstance like this? Maybe not treating a patient, but interviewing for a most coveted job, giving the most important sales presentation, or pushing yourself to win that race? Fortunately, the outcome that morning was positive, the important medical tests were highly informative for the course of her care and the patient made it through the night. There are situations like that that arise often, and often unexpected, and you have to be prepared to make those yours. Stay focused and be at your best, always.
Here at Clarex, we are all about Eliminating Mental Limits. Our mental clarity recovery formula can offer a lot-whether you’re looking for a study aid, intelligent workout, or hangover relief. Now that you have an idea what Clarex is all about, it’s time to meet the team that is Clarex.
Dr. Eugene Chan formulated Clarex as a study aid. Caffeine free, Clarex all-naturally provided focus without and crash or side effects. A Harvard graduate, Dr. Chan discovered Clarex increased brain function while increasing concentration and motor skills. His work has been featured in several magazines, including Esquire, Forbes, Fortune, Newsweek, and the New York Times. He is the Founder, President, and Chief Scientific Officer of the DNA Medicine Institute, an organization focused on advancing patient care, alleviating human suffering, and treating disease through innovation.
Eric Ballenger, Florida native and Clarex Marketing Director takes Clarex daily. As a former competitive bodybuilder, Eric knows what it takes to go the distance, and Clarex is one of those necessities. He saw the benefit of Clarex, realizing it helped increase his concentration, leading to more productive workouts. The “intelligent workout” with Clarex helps you make the most of your workout, giving you 100% focus on the task at hand.
So there’s a quick introduction to some of the Clarex team! Feel free to comment with any questions for either Dr. Chan or Eric to reply to in upcoming posts.
Experience no limits safely with Clarex, and check back often!
Here at Clarex, we are all about eliminating mental limits. With no caffeine or side effects, our all natural product promotes “the intelligent workout” or the perfect hangover relief.
Our blog will be featuring posts from Dr. Eugene Chan, Harvard MD and scientific innovator. Dr. Chan was voted one of the top 10 minds under 35 in the world by Esquire magazine. He is the innovative mind behind Clarex. There will also be posts from Eric Ballenger, fitness enthusiast and former competitor bodybuilder. They will both have weekly posts discussing their areas of expertise, and how Clarex should become a part of your daily routine.
Check back often, there’s always new content being posted.
You can reach us online at www.clarexonline.com.
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Our next post will introduce each team member and allow you to ask questions about how Clarex can help you in your daily life.
Have a day filled with focus, and eliminate mental limits with Clarex!